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Immunohistological identification of cell subsets in human gingival after local treatment for gingivitis or periodontitis
Author(s) -
Jully Jean Marie,
Béné Marie Christine,
Martin Gérard,
Faure Gilbert
Publication year - 1986
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1986.tb01464.x
Subject(s) - gingivitis , periodontitis , antigen , immune system , medicine , chronic periodontitis , immunology , population , pathology , human leukocyte antigen , cell , inflammation , biology , dentistry , environmental health , genetics
The cellular infiltrate present in human diseased gingiva was analyzed in biopsies from 12 patients with gingivitis or periodontitis. The samples studied had been obtained in the course of surgery at inflammatory sites remaining after institution of periodontal treatment. Histological and immunological techniques were used to identify macrophages, B‐cells, plasma‐cells, T‐cells and T cell subsets, as well as cells expressing class II HLA membrane antigens. T‐cells appeared as the predominant population, but plasma‐cells were also visualized in nearly all samples. Both OKT4+ and OKT8+ cells were seen in all cases, the latter being more numerous in periodontitis patients. Interdigitating‐like cells were observed, positively labelled for class II antigens, as well as macrophages which were more numerous in periodontitis patients. These results suggest the participation of all components of the immune response in gingival disease, in a way resembling chronic recurrent inflammatory diseases.