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Plaque control with chlorhexidine and D‐301, a quaternary ammonium compound
Author(s) -
Saxer U. P.,
Mörmann W.,
Firestone A. R.,
Eltink B.
Publication year - 1982
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1982.tb01232.x
Subject(s) - chlorhexidine , dentistry , medicine , dental plaque , oral hygiene , crossover study , ammonium , chemistry , placebo , pathology , alternative medicine , organic chemistry
Eighteen female dental hygiene student took part in a double‐Wind, crossover clinical trial of equimolar (2.2 mmol) rinsing solutions of D‐301, a quaternary ammonium compound and chlorhexidine digluconate. Rinsings were partly supervised, test periods were 7 days (5 days without oral hygiene) with a 1‐week interval. Plaque formation was significantly reduced by both test solutions versus the control: on not precleaned tooth surfaces plaque formation was equally inhibited by the chlorhexidine and D‐301 mouthrinses. On precleaned surfaces D‐301 significantly inhibited plaque formation compared with the control rinse, but was less effective than chlorhexidine. There was no significant change in the FBI, a measure of gingival inflammation, during any of the test periods. Staining of teeth and tongue was judged as equal after chlorhexidine and D‐301 use. Reports of taste and gastric disturbances were minimal but more frequent during the D‐301 test period.