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Periodontal therapy by local delivery of tetracycline
Author(s) -
Goodson J. M.,
Haffajee A.,
Socransky S. S.
Publication year - 1979
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1979.tb02186.x
Subject(s) - gingival sulcus , gingival and periodontal pocket , tetracycline , periodontal disease , dentistry , medicine , sulcus , drug delivery , chemistry , microbiology and biotechnology , biology , antibiotics , surgery , organic chemistry
. The present investigation assessed the feasibility of treating periodontal disease by controlled delivery of antibacterial agents from within periodontal pockets. Tetra‐cycline‐filled hollow fibers placed in the gingival sulcus were shown to have a dramatic effect both on the periodontal microflora and clinical manifestations of disease. Furthermore, it was found that drug‐filled cellulose acetate hollow fibers are biologically compatible with the environment and can be manipulated by dental personnel to provide drug therapy with less than 1/1000 the amount of tetracycline that would have been used for systemic therapy. Of theoretical importance is the observation that virtual elimination of spirochetes from the gingival sulcus is possible by a single placement of tetracycline‐filled hollow fibers, and spirochetes, ones eliminated from a site, do not rapidly recolonize despite the persistence of viable organisms elsewhere in the mouth.