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Influence of teeth, plaque and dentures on the retention of chlorhexidine in the human oral cavity
Author(s) -
Bonesvoll P.,
Olsen I.
Publication year - 1974
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1974.tb01260.x
Subject(s) - dentures , chlorhexidine , dentistry , saliva , dental plaque , oral cavity , chemistry , oral hygiene , medicine , biochemistry
The retention of chlorhexidine in the oral cavity after rinsing with 10 ml 0.2 % [ 14 C]‐chlorhexidine‐digluconate for 1 min was found to be 3.8 mg (S.D. = 1.4 mg) in a group of 12 edentulous patients. By comparison, the mean oral retention in 10 dental students with cleaned and polished teeth was 4.6 mg (S.D. = 0.7 mg). Measurement of the retention in 6 subjects before and after extensive tooth extractions showed no major influence of the teeth on the chlorhexidine retention. Plaque accumulation for 6 d increased the mean Plaque Index from 0 to 0.82 (S.D.=0.35). The corresponding mean oral retention increased significantly from 4.6 mg (S.D.=0.7 mg) to 5.6 mg (S.D.=1.1 mg). Chlorhexidine was readily bound to acrylic resin dentures. A mean binding of 4.2 mg (S.D.=2.0) after 16 min immersion in 110 ml 0.2% chlorhexidine solution was found. The [ 14 C] activity of the saliva showed a sharp fall during the first few hours after insertion of the dentures, followed by a slow release, with activity still present after 24 h.