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Influence of a collagen membrane and recombinant platelet‐derived growth factor on vertical bone augmentation in implant‐fixed deproteinized bovine bone – animal pilot study
Author(s) -
Kämmerer P.W.,
Palarie V.,
Schiegnitz E.,
Nacu V.,
Draenert F.G.,
AlNawas B.
Publication year - 2013
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/j.1600-0501.2012.02534.x
Subject(s) - membrane , platelet derived growth factor receptor , growth factor , chemistry , platelet derived growth factor , implant , biomedical engineering , medicine , biochemistry , surgery , receptor
Objectives Combinations of bone substitute block materials with membrane techniques as well as with growth factors are possible options to enhance the prognosis of vertical bone augmentation. Therefore, the aim of the pilot study was to compare the influence of a collagen membrane and a signal protein (rh PDGF ‐ BB ) on vertical bone augmentation with a stable fixed block material (deproteinized bovine bone [ DBB ]). Materials and methods In 12 rabbits, a DBB ‐block was implant‐fixed on the tibia in a split‐leg‐design. Included were: DBB only (control), DBB + collagen membrane (test), DBB + rh PDGF ‐ BB (test) and DBB + rh PDGF ‐ BB + collagen membrane (test). 24 samples were examined after 3 ( n = 12) and 6 weeks ( n = 12). Calculated parameters were new bone area ( NBA ;%), new vertical bone height ( VBH ; mm). Due to the pilot character of this study, single values are shown descriptively only. Results After 3 weeks, there were constant higher NBA values in the rh PDGF ‐ BB ‐group without membrane ( NBA (%) DBB : 30/16/4; DBB + membrane: 25/17/7, DBB + rh PDGF ‐ BB : 40/33/34, DBB + rh PDGF ‐ BB + membrane: 0/30/16; VBH (mm) DBB : 1.2/1.2/1, DBB + membrane: 0.7/0.9/1, DBB + rh PDGF ‐ BB : 0.7/0.9/1, DBB + rh PDGF ‐ BB + membrane: 0/1.1/1). After 6 weeks, both membrane groups showed a constant higher NBA and VBH independent to the use of rh PDGF ‐ BB ( NBA DBB : 3/0/5, DBB + membrane: 20/35/31, DBB + rh PDGF ‐ BB : 5/8/4, DBB + rh PDGF ‐ BB + membrane: 31/35/40; VBH DBB : 0.3/0.3/0.6, DBB + membrane: 1.6/2.4/2.1, DBB + rh PDGF ‐ BB : 0.4/0.7/0.8, DBB + rh PDGF ‐ BB + membrane: 1.8/2/1.8). Conclusions For vertical augmentation, the addition of rh PDGF ‐ BB to DBB ‐blocks may increase early bone growth. In the later phase, the use of a collagen membrane enhances new bone volume and height to a significant greater extend. Even if the results are higher than those in the non‐membrane groups, the low gain of bone after the short time periods still needs improvement.