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Osseointegration of SLA ctive implants in diabetic pigs
Author(s) -
Schlegel K. A.,
Prechtl C.,
Möst T.,
Seidl C.,
Lutz R.,
Wilmowsky C.
Publication year - 2013
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/j.1600-0501.2011.02380.x
Subject(s) - osseointegration , implant , osteocalcin , medicine , dentistry , diabetes mellitus , calvaria , surgery , endocrinology , chemistry , alkaline phosphatase , biochemistry , in vitro , enzyme
Objectives Diabetes mellitus is currently classified as a relative contraindication for implant treatment because of microangiopathies with the consequence of impaired bone regeneration and higher rates of implant failure. The study aim was to investigate peri‐implant bone formation in a diabetic animal model in comparison to healthy animals and to evaluate the differences between conventional ( SLA ® ) and modified ( SLA ctive ® ) titanium implant surfaces on osseointegration. Material and methods Each six implants were placed in the calvaria of 11 diabetic and 4 healthy domestic pigs. At 30 and 90 days after implant placement, the bone‐to‐implant contact ( BIC ) and bone density ( BD ) were appraised. Additionally, the expression of the bone‐matrix proteins collagen type I and osteocalcin was evaluated at both points in time by using immunohistochemical staining methods. Results Overall, BIC was reduced in the diabetic group at 30 and 90 days. After 90 days, the SLA ctive ® implants showed significantly higher BIC s compared with the SLA ® implants in diabetic animals. Peri‐implant BD was higher in the SLA ctive ® group at 30 and 90 days in healthy and diabetic animals. Collagen type I protein expression was higher using SLA ® implants in diabetic pigs at 30 days. Values for osteocalcin expression were not consistent. Conclusions The results indicate the negative effect of untreated diabetes mellitus on early osseointegration of dental implants. The modified SLA ® surface ( SLA ctive ® ) elicited an accelerated osseointegration of dental implants, suggesting that a better prognosis for implant treatment of diabetic patients is possible.