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Clinical, histologic and histomorphometric evaluation of socket preservation using a synthetic nanocrystalline hydroxyapatite in comparison with a bovine xenograft: a randomized clinical trial
Author(s) -
Gholami Gholam Ali,
Najafi Babak,
Mashhadiabbas Fatemeh,
Goetz Werner,
Najafi Siamak
Publication year - 2012
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/j.1600-0501.2011.02288.x
Subject(s) - trephine , dentistry , calipers , molar , extraction (chemistry) , medicine , chemistry , nuclear medicine , surgery , chromatography , physics , optics
Objectives The aim of this study was to compare a nanocrystalline hydroxyapatite ( NCHA ), NanoBone ® and a deproteinized bovine bone mineral ( DBBM ), Bio‐Oss ® with a collagen membrane on the horizontal ridge width alterations following tooth extraction, in addition to histologic aspects of the grafted extraction sockets. Material and methods In this randomized clinical trial, 28 symmetrical, non‐molar, extraction sockets using a split‐mouth design in 12 patients (eight women and four men; aged 21–60; mean 44.6 ± 11.4 years), were randomly selected in the first group to be grafted with DBBM granules covered with a collagen membrane and in the other group grafted with NCHA covered with a collagen membrane. Following extraction horizontal ridge width was measured using caliper and was blindly compared to the dimensions measured prior to implant placement, at the 6‐ to 8‐month follow‐up. Subsequently, a 2 × 6 mm trephine core was obtained with aid of acrylic stent and routine histologic preparation was performed on the specimens. Results The width of the DBBM group decreased from 7.75 ± 1.55 to 6.68 ± 1.85 mm ( P < 0.05), whereas the width of the NCHA group decreased from 7.36 ± 1.94 to 6.43 ± 2.08 mm ( P < 0.05). The mean between‐group difference did not reach statistical significance ( P = 0.62). Furthermore, histologic and histomorphometric analyses revealed 28.63 ± 12.53% vital bone in NCHA group vs. 27.35 ± 12.39% in DBBM group, and no statistically significant difference between the groups ( P = 0.68). Conclusion Socket preservation using either NCHA or DBBM in combination with collagen membrane, results in similar, limited horizontal ridge width alterations following tooth extraction.