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Blood responses to titanium surface with TiO 2 nano‐mesh structure
Author(s) -
Huang HerHsiung,
Chen JingYi,
Lin MauChin,
Wang YuTsai,
Lee TienLin,
Chen LiKai
Publication year - 2012
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/j.1600-0501.2010.02152.x
Subject(s) - anodizing , materials science , titanium , diffractometer , scanning electron microscope , field emission microscopy , nano , layer (electronics) , chemical engineering , nanotechnology , composite material , metallurgy , aluminium , optics , physics , engineering , diffraction
Objectives: The goal of this study was to enhance the blood responses to titanium (Ti) surfaces used for dental implant application through the formation of a TiO 2 nano‐mesh surface layer produced by a fast electrochemical anodization treatment.Material and methods: Electrochemical anodization treatments with different anodization currents and temperatures in an alkaline solution were used to create a nano‐mesh oxide layer on polished Ti surface. Surface characterizations of the mesh structure were carried out using thin‐film X‐ray diffractometer, field‐emission scanning electron microscope, and atomic force microscope. The blood responses, including the blood‐clotting ability and platelet adhesion morphology, to the test Ti surfaces were evaluated. The blood‐clotting ability, in terms of optical density of blood, was statistically analyzed using a nonparametric method, Kruskal–Wallis test, for the factor of anodization treatment.Results: A multilayer TiO 2 nano‐mesh structure was rapidly formed on the polished Ti surface using a simple electrochemical anodization treatment in an alkaline solution. The TiO 2 nano‐mesh had an average mesh size between 34 and 93 nm, depending on the anodization current and temperature. The features on the TiO 2 nano‐mesh structure on the anodized Ti surface were of a similar size scale as blood proteins, giving the material better blood clot ability ( P <0.05) and improved platelet activation and aggregation as compared with an untreated polished Ti surface.Conclusions: The formation of TiO 2 nano‐mesh on the Ti surfaces was shown to enhance blood responses, which we expect to promote cell growth in the application of dental implants.To cite this article:
Huang H‐H, Chen J‐Y, Lin M‐C, Wang Y‐T, Lee T‐L, Chen L‐K. Blood responses to titanium surface with TiO 2 nano‐mesh structure.
Clin. Oral Impl. Res . 23 , 2012; 379–383.
doi: 10.1111/j.1600‐0501.2010.02152.x