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Titanium nitride oxide coating on rough titanium stimulates the proliferation of human primary osteoblasts
Author(s) -
Durual S.,
Pernet F.,
Rieder P.,
Mekki M.,
CattaniLorente M.,
Wiskott H. W. A.
Publication year - 2011
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/j.1600-0501.2010.02033.x
Subject(s) - osseointegration , titanium , osteoblast , osteocalcin , alkaline phosphatase , osteoprotegerin , materials science , coating , cell growth , zirconium nitride , implant , chemistry , biomedical engineering , nitride , nanotechnology , metallurgy , in vitro , biochemistry , titanium nitride , layer (electronics) , medicine , surgery , enzyme , activator (genetics) , gene
Objectives: Titanium is widely used in contemporary endosseous implantology and there is considerable thrust to further promote osseointegration by implant surface modifications. The aim of this study was to evaluate the effect of a titanium–nitride–oxide (TiNOx) coating on commercially pure microroughened titanium by assessing the proliferation and differentiation of human primary osteoblasts. Materials and methods: Cell proliferation, gene expression, alkaline phosphatase activity, osteoprotegerin and osteocalcin secretion were analyzed for a time course of 3 weeks, with or without additional stimulation by 1.25(OH) 2 vitamin D 3 100 nM. Results: A 1.5‐fold increase in the proliferation rate of cells grown on TiNOx‐coated titanium as compared with uncoated surfaces was observed. SEM views indicated that the cells' normal morphology with their numerous extensions was maintained. The differentiation process on the TiNOx surface was only affected to a minor degree and translated into a slight delay in osteoblast maturation when compared to uncoated titanium. Conclusion: Pending confirmation of these results in vivo , TiNOx coatings could potentially accelerate and enhance osseointegration. To cite this article:
Durual S, Pernet F, Rieder P, Mekki M, Cattani‐Lorente M, Wiskott H. W. A. Titanium nitride oxide coating on rough titanium stimulates the proliferation of human primary osteoblasts.
Clin. Oral Impl. Res . 22 , 2011; 552–559
doi: 10.1111/j.1600‐0501.2010.02033.x