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Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized clinical trial
Author(s) -
Rickert D.,
Sauerbier S.,
Nagursky H.,
Menne D.,
Vissink A.,
Raghoebar G.M.
Publication year - 2011
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/j.1600-0501.2010.01981.x
Subject(s) - medicine , iliac crest , dentistry , maxillary sinus , sinus (botany) , maxilla , bone mineral , surgery , pathology , osteoporosis , biology , botany , genus
Aim: To assess whether differences occur in bone formation after maxillary sinus floor elevation surgery with bovine bone mineral (BioOss ® ) mixed with autogenous bone or autogenous stem cells. The primary endpoint was the percentage of new bone three months after the elevation procedure. Material and methods: In a randomized, controlled split‐mouth design, in 12 consecutive patients (age 60.8 ± 5.9 years, range 48–69 years) needing reconstruction of their atrophic maxilla, a bilateral sinus floor augmentation procedure was performed. Randomly, on one side the augmentation procedure was performed with bovine bone mineral (BioOss ® ) seeded with mononuclear stem cells harvested from the posterior iliac crest (test group) while BioOss ® mixed with autogenous bone (harvested from the retromolar area) was applied on the contra‐lateral side (control group). On 14.8 ± 0.7 weeks after the sinus floor elevation, biopsies from the reconstructed areas were taken at the spots where subsequently the endosseous implants were placed. The biopsies were histomorphometrically analyzed. Results: Significantly more bone formation was observed in the test group (17.7 ± 7.3%) when compared with the control group (12.0%± 6.6; P =0.026). In both the test and control group, all implants could be placed with primary stability. In one patient, not all biopsies contained BioOss ® . This patient was excluded from analysis. Conclusion: Mesenchymal stem cells seeded on BioOss ® particles can induce the formation of a sufficient volume of new bone to enable the reliable placement of implants within a time frame comparable with that of applying either solely autogenous bone or a mixture of autogenous bone and BioOss ® . This technique could be an alternative to using autografts. To cite this article: Rickert D, Sauerbier S, Nagursky H, Menne D, Vissink A, Raghoebar GM. Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized clinical trial.
Clin. Oral Impl. Res . 22 , 2011; 251–258.
doi: 10.1111/j.1600‐0501.2010.01981.x