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Bone substitute as an on‐lay graft on rat tibia
Author(s) -
Truedsson A.,
Wang J.S.,
Lindberg P.,
Gordh M.,
Sunzel B.,
Warfvinge G.
Publication year - 2010
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/j.1600-0501.2009.01875.x
Subject(s) - cortical bone , tibia , cortex (anatomy) , medicine , anatomy , biology , neuroscience
Objectives: To investigate the capacity of Cerament ® , an injectable bone substitute, to guide bone generation from a cortical surface. Materials and method: Cerament ® was applied to the cortical surface of rat tibiae and investigated histologically after 3, 6 and 12 weeks, using a procedure similar to that performed in sham‐operated rats. Results: In both groups, the thickness of the bone cortex increased significantly from 473±58 μm (mean±SD) at day 0 to 1193±255 μm (Cerament ® ) and 942±323 μm (sham) after 3 weeks. In the Cerament ® group, the new bone thickness remained constant (1258±288 μm) until the end of the experiment at 12 weeks, while the sham group demonstrated a return to initial cortical thickness (591±73 μm) at 12 weeks. The newly formed bone in the Cerament ® group was highly trabecular after 3 weeks but attained a normal trabecular structure of the cortex after 12 weeks. Conclusion: Cerament ® may guide bone generation from an intact cortical bone surface. Although bone remodeling speed may differ between rats and humans, our study indicates that Cerament ® may become a useful alternative to autologous bone, both to fill defects and to increase bone volume by cortical augmentation. To cite this article:
Truedsson A, Wang J‐S, Lindberg P, Gordh M, Sunzel B, Warfvinge G. Bone substitute as an on‐lay graft on rat tibia. Clin. Oral Impl. Res . 21 , 2010; 424–429.
doi: 10.1111/j.1600‐0501.2009.01875.x