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Biological properties of a biomimetic membrane for guided tissue regeneration: a study in rat calvarial defects
Author(s) -
Zhang Jingchao,
Huang Cui,
Xu Qian,
Mo Anchun,
Li Jidong,
Zuo Yi
Publication year - 2010
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/j.1600-0501.2009.01857.x
Subject(s) - membrane , scanning electron microscope , materials science , polytetrafluoroethylene , regeneration (biology) , alkaline phosphatase , biomedical engineering , polyamide , blank , dentistry , chemistry , composite material , medicine , biology , organic chemistry , biochemistry , enzyme , microbiology and biotechnology
Objective: The biological properties of nano‐hydroxyapatite/polyamide (nHA/PA66) membrane as a guided tissue regeneration barrier were investigated based on a critical‐size calvarial defect model. Material and methods: Thirty‐six Sprague–Dawley rats were divided into four groups: nHA/PA66 membranes, control treated with expanded polytetrafluoroethylene (e‐PTFE) membranes, control treated with PA membranes and blank. Bone regeneration in each group was evaluated using morphological, serological, radiographic and histological techniques at 1, 4 and 8 weeks, respectively, post‐operation. Results: Slight degradation of nHA/PA66 membranes was observed by a scanning electron microscope (SEM) at 4 and 8 weeks. The serum alkaline phosphatase level and the integral optical density of neo‐bone were significantly higher in the nHA/PA66 group than those in the PA group and blank ( P <0.05). Radiographic and histological analysis showed a fully closed cranial defect for both the nHA/PA66 group and the e‐PTFE group at 8 weeks. No remarkable difference was found between the nHA/PA66 group and the e‐PTFE group at each time interval. Conclusion: nHA/PA66 membrane promoted bone regeneration as effectively as conventional e‐PTFE membrane. Based on a rat study, nHA/PA66 membrane provides a promising alternative to e‐PTFE membrane due to the absence of requirement for a second surgery. To cite this article:
Zhang JC, Huang C, Xu Q, Mo AC, Li JD, Zuo Y. Biological properties of a biomimetic membrane for guided tissue regeneration: a study in rat calvarial defects.
Clin. Oral Impl. Res . 21 , 2010; 392–397.
doi: 10.1111/j.1600‐0501.2009.01857.x