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Healing of rabbit calvarial bone defects using biphasic calcium phosphate ceramics made of submicron‐sized grains with a hierarchical pore structure
Author(s) -
Park JinWoo,
Kim EunSuk,
Jang JeHee,
Suh JoYoung,
Park KwangBum,
Hanawa Takao
Publication year - 2010
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/j.1600-0501.2009.01846.x
Subject(s) - calvaria , osteon , scanning electron microscope , materials science , calcium , bone formation , bone healing , microporous material , chemistry , biomedical engineering , dentistry , anatomy , cortical bone , composite material , medicine , metallurgy , biochemistry , in vitro , endocrinology
Objectives: This study investigated the efficacy of new bone graft substitutes – biphasic calcium phosphates (BCP) made of submicron‐sized grains with fully interconnected wide‐range micron‐scale pores in two different macrodesigns: donut shaped with a 300–400 μm central macropore (n‐BCP‐1) or rod‐shaped (n‐BCP‐2) – in the healing of rabbit calvarial defects, and compared their bone‐healing properties with those of various commercial bone substitutes, which included substitutes with similar BCP composition (MBCP and Osteon), anorganic bovine bone (Bio‐Oss), and β‐TCP (Cerasorb). Material and methods: The surface morphology of the bone substitutes was investigated using scanning electron microscopy (SEM). Defects 8 mm in diameter were created in the calvaria of 30 adult male New Zealand White rabbits and were filled with six types of bone substitutes. The percentage of newly formed bone (NB%) was evaluated histomorphometrically 4 and 8 weeks after implantation. Results: SEM observation showed submicron‐sized grains with fully interconnected micropore structures in the n‐BCP‐1 and n‐BCP‐2 groups; these groups also showed considerable new bone formation in inner micropores as well as on the outer surfaces. The n‐BCP‐1 group exhibited enhanced new bone formation and direct ingrowth of bone tissue with blood vessels into central pores. Histomorphometric analysis showed significantly greater NB% in the n‐BCP‐1 group when compared with the other groups at 4 and 8 weeks ( P <0.05). Conclusion: A new BCP ceramics made of submicron‐sized grains with a hierarchical pore structure was an effective osteoconductive material for the treatment of osseous defects of rabbit calvaria. To cite this article:
Park J‐W, Kim E‐S, Jang J‐H, Suh J‐Y, Park K‐B, Hanawa T. Healing of rabbit calvarial bone defects using biphasic calcium phosphate ceramics made of submicron‐sized grains with a hierarchical pore structure.
Clin. Oral Impl. Res . 21 , 2010; 268–276.
doi: 10.1111/j.1600‐0501.2009.01846.x