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Bone repair and augmentation using block of sintered bovine‐derived anorganic bone graft in cranial bone defect model
Author(s) -
Cestari Tania Mary,
Granjeiro José Mauro,
De Assis Gerson Francisco,
Garlet Gustavo Pompermaier,
Taga Rumio
Publication year - 2009
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/j.1600-0501.2008.01659.x
Subject(s) - osseointegration , connective tissue , dentistry , significant difference , artificial bone , medicine , anatomy , surgery , implant , pathology
Objective: To histomorphometrically investigate the repair of critical size defects (CSDs) and bone augmentation in cranial walls using block of sintered bovine‐derived anorganic bone (sBDAB) graft. Material and methods: Forty guinea‐pigs were divided into test ( n =20) and CSD control ( n =20) groups. In each animal, a full‐thickness bone defect with 9.5 mm diameter was made in the frontal bone. The defects were filled with an sBDAB block soaked in blood in the test group and with blood clot in the CSD control group. The skulls were collected at 0 h ( n =2) and 30, 90 and 180 days ( n =6/group and period) postoperatively. The volume density and total volume of newly formed bone, sBDAB, blood vessels and connective tissue, vertical thickness of removed bone plug, sBDAB block and graft area were evaluated. Results: The vertical thickness of the adapted sBDAB block was 3.8 times higher than that of the removed bone plug and did not show significant difference between periods, filling in average 29.8% of the total graft region. The sBDAB block exhibited complete osseointegration with the borders of the defect at 90 days. At 90 and 180 days, the vertical thickness of the graft was 279% in the average, and the total volume of bone augmentation was, respectively, 78.8% and 148.5% higher compared with the removed bone plug. The defects of the CDS control group showed limited osteogenesis and filling by connective tissue plus tegument. Conclusion: The sBDAB block can be used to promote repair of CSDs and bone augmentation in the craniomaxillofacial region, due to its good osteoconductive and slow resorptive properties.