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Sinus floor augmentation with recombinant human growth and differentiation factor‐5 (rhGDF‐5): a pilot study in the Goettingen miniature pig comparing autogenous bone and rhGDF‐5
Author(s) -
Gruber Rudolf Matthias,
Ludwig Arwed,
Merten HansAlbert,
Pippig Susanne,
Kramer FranzJosef,
Schliephake Henning
Publication year - 2009
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/j.1600-0501.2008.01628.x
Subject(s) - maxillary sinus , anatomy , dentistry , biology , biomedical engineering , medicine
Aim: The aim of this study was to test the hypothesis that recombinant human growth and differentiation factor‐5 (rhGDF‐5) in combination with a β‐tricalcium phosphate (β‐TCP) scaffold material results in superior bone formation in sinus floor augmentations in miniature pigs compared with a particulated autogenous bone graft combined with the scaffold material. Material and methods: Six adult female Goettingen minipigs underwent a maxillary sinus floor augmentation procedure. In a split‐mouth design, the sinus floors were augmented with β‐TCP mixed with autogenous cortical bone chips, in a ratio of approximately 1 : 1, on one side. The contralateral test site was augmented using β‐TCP coated with two concentrations of rhGDF‐5 (400 μg rhGDF‐5/g β‐TCP or 800 μg rhGDF‐5/g β‐TCP; three animals in each case). Simultaneously, one dental implant was inserted into each sinus floor augmentation. After 12 weeks, a histological and histomorphometric assessment of non‐decalcified histological specimens was made. Results: There were significantly higher mean values of volume density of newly formed bone using β‐TCP coated with two concentrations of rhGDF‐5 (400 μg: 32.9%; 800 μg: 23.9%) than with the corresponding control (autogenous bone/β‐TCP) (14.6%, 12.9%) ( P =0.012, P =0.049). The bone‐to‐implant contact rates (BIC) were significantly enhanced in test sites (400 μg: 84.2%; 800 μg: 69.8%) compared with the corresponding control sites (24.8%, 40.8%) ( P =.027, P =.045). Conclusion: rhGDF‐5 delivered on β‐TCP significantly enhanced bone formation compared with β‐TCP combined with autogenous bone in sinus lift procedures in miniature pigs.