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Topical application of statin affects bone healing around implants
Author(s) -
Moriyama Yasuko,
Ayukawa Yasunori,
Ogino Yoichiro,
Atsuta Ikiru,
Koyano Kiyoshi
Publication year - 2008
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/j.1600-0501.2007.01508.x
Subject(s) - fluvastatin , implant , statin , medicine , osseointegration , dentistry , bone healing , urology , surgery , simvastatin
Objectives: 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors (statins) are widely used for hyperlipidemia. Recent studies demonstrate that statins stimulate bone morphogenetic protein‐2 expression and lead to bone formation. The aim of this study was to evaluate whether the topical application of statin enhances the osteogenesis around a titanium implant. Materials and methods: Ten‐week‐old female rats received pure titanium rods in both tibiae with or without fluvastatin. Propylene glycol alginate (PGA) was used as a carrier. The rats were divided into five groups: implant‐only group, implant with PGA group, low‐dose group [implant+PGA containing 3 μg of fluvastatin (FS)], medium‐dose group (15 μg of FS), and high‐dose group (75 μg of FS). The animals were sacrificed at 1 and 2 weeks after implantation. Peri‐implant bone formation was assessed by histomorphometric procedures, i.e., measuring the bone–implant contact (BIC) and peri‐implant bone volume (BV). A mechanical push‐out test was also performed to evaluate the implant fixation strength. Statistical differences among the groups were determined by ANOVA and P <0.05 was considered significant. Results: At week 1, there was no significant difference in BIC among the groups, however, BV and the push‐out strength were significantly higher in the high‐dose group than in the implant‐only group. At week 2, BIC and BV had significantly increased in the high‐dose group in comparison with the non‐statin groups. The fluvastatin‐treatment group showed a significant increase in push‐out strength compared with the non‐statin groups. Conclusion: Our histomorphometrical and mechanical evaluations revealed the positive effect of topically applied fluvastatin on the bone around the implant.