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Knochenheilung in chirurgisch kreierten Defekten, welche entweder mit bioaktiven Glaspartikeln, einer Kalziumsulfatmembran oder mit einer Kombination von beiden Materialien behandelt wurden. Eine histologische und histometrische Studie an Ratten
Author(s) -
Melo Luiz G. N.,
Nagata Maria J. H.,
Bosco Alvaro F.,
Ribeiro Luciana L. G.,
Leite Cristiane M.
Publication year - 2005
Publication title -
clinical oral implants research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.407
H-Index - 161
eISSN - 1600-0501
pISSN - 0905-7161
DOI - 10.1111/j.1600-0501.2005.01090.x
Subject(s) - bioactive glass , calcium , sulfate , chemistry , bone healing , dentistry , bone formation , surgery , medicine , endocrinology , organic chemistry
Objective: The purpose of this study was to histologically analyze the influence of bioactive glass and/or a calcium sulfate barrier on bone healing in surgically created defects in rat tibias. Material and methods: Sixty‐four rats were divided into 4 groups: C (control), CS (calcium sulfate), BG (bioactive glass), and BG/CS (bioactive glass/calcium sulfate). A surgical defect was created in the tibia of each animal. In Group CS, a calcium sulfate barrier was placed to cover the defect. In Group BG the defect was filled with bioactive glass. In Group BG/CS, it was filled with bioactive glass and protected by a barrier of calcium sulfate. Animals were sacrificed at 10 or 30 days post‐operative. The formation of new bone in the cortical area of the defect was evaluated histomorphometrically. Results: At 10 days post‐operative, Group C presented significantly more bone formation than Groups CS, BG, or BG/CS. No statistically significant differences were found between the experimental groups. At 30 days post‐operative, Group C demonstrated significantly more bone formation than the experimental groups. Groups CS and BG/CS showed significantly more bone formation than Group BG. No statistically significant differences were found between Group CS and BG/CS. Conclusions: (a) the control groups had significantly more bone formation than the experimental groups; (b) at 10 days post‐operative, no significant differences were found between any of the experimental groups; and (c) at 30 days post‐operative, the groups with a calcium sulfate barrier had significantly more bone formation than the group that used bioactive glass only.