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Is it possible to predict low‐volume and insignificant prostate cancer by core needle biopsies?
Author(s) -
Berg Kasper Drimer,
Toft Birgitte Grønkaer,
Røder Martin Andreas,
Brasso Klaus,
Vainer Ben,
Iversen Peter
Publication year - 2013
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2012.02965.x
Subject(s) - medicine , prostate cancer , prostatectomy , prostate , biopsy , urology , predictive value , prostate specific antigen , cancer , radiology
In an attempt to minimize overtreatment of localized prostate cancer ( PCa ) active surveillance ( AS ) and minor invasive procedures have received increased attention. We investigated the accuracy of pre‐operative findings in defining insignificant disease and distinguishing between unilateral/unifocal and bilateral/multifocal PCa . One‐hundred and sixty patients undergoing radical prostatectomy were included. Histology reports from the biopsies and matching prostatectomies were compared. Three definitions of insignificant cancer were used: InsigE: tumour volume ≤0.5 mL; InsigW: tumour volume ≤1.3 mL; InsigM: tumour ≤5% of total prostate volume and prostate‐specific antigen ( PSA ) ≤10 ng/mL. In all definitions, Gleason score (GS) was ≤6 and the tumour was organ confined. Biopsies alone performed poorly as a predictor of unifocal and unilateral cancer in the prostatectomy specimens with positive predictive values of 17.8% and 18.9% respectively. Inclusion of other clinical and biochemical parameters did not significantly increase the predictive value. However, the combination of GS ≤ 6, PSA ≤ 10 ng/mL and unifocal or unilateral cancer in biopsy cores resulted in a positive predictive value of 61.1%, 38.9% and 12.0%, respectively, for identifying InsigM , InsigW and InsigE in the prostate specimen. Conclusively, routine prostate biopsies cannot predict unifocal and unilateral PCa , and must be regarded insufficient to select patients for focal therapy. Although candidates for AS may be identified using standard biopsies, a considerable fraction of patients will be understaged. There is a need for more precise diagnostic tools to assess intraprostatic tumour growth.