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Limited prognostic value of tissue protein expression levels of cyclin E in D anish ovarian cancer patients: from the D anish ‘ MALOVA ’ ovarian cancer study
Author(s) -
Heeran Mel C.,
Høgdall Claus K.,
Kjaer Susanne K.,
Christensen Lise,
Blaakaer Jan,
Christensen Ib Jarle,
Hogdall Estrid V. S.
Publication year - 2012
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2012.02913.x
Subject(s) - serous fluid , ovarian cancer , medicine , oncology , serous ovarian cancer , cancer , ovarian tumor , univariate analysis , ovary , multivariate analysis , pathology
The primary objective of this study was to assess the expression of cyclin E in tumour tissues from 661 patients with epithelial ovarian tumours. The second was to evaluate whether cyclin E tissue expression levels correlate with clinico‐pathological parameters and prognosis of the disease. Using tissue arrays ( TA ), we analysed the cyclin E expression levels in tissues from 168 women with borderline ovarian tumours ( BOT ) (147 stage I, 4 stage II, 17 stage III) and 493 Ovarian cancer ( OC ) patients (127 stage I, 45 stage II, 276 stage III, 45 stage IV). Using a 10% cut‐off level for cyclin E overexpression, 20% of the BOT s were positive with a higher proportion of serous than mucinous tumours. Sixty‐two per cent of the OC s were positive for cyclin E expression with the highest percentage found in clear cell carcinomas. Results based on univariate and multivariate survival analyses with a 10% cut‐off value showed that cyclin E had no independent prognostic value. In conclusion, we found cyclin E expression in tumour tissue to be of limited prognostic value to D anish OC patients.