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Interaction of viral oncoproteins with cellular target molecules: infection with high‐risk vs low‐risk human papillomaviruses
Author(s) -
PIM DAVID,
BANKS LAWRENCE
Publication year - 2010
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2010.02618.x
Subject(s) - tropism , hpv infection , biology , virology , head and neck , immunology , medicine , cervical cancer , cancer research , cancer , virus , genetics , surgery
Pim D, Banks L. Interaction of viral oncoproteins with cellular target molecules: infection with high‐risk vs low‐risk human papillomaviruses. APMIS 2010; 118: 471–493. Persistent infection by a subgroup of so‐called high‐risk human papillomaviruses (HPVs) that have a tropism for mucosal epithelia has been defined as the cause of more than 98% of cervical carcinomas as well as a high proportion of other cancers of the anogenital region. Infection of squamous epithelial tissues in the head and neck region by these same high‐risk HPVs is also associated with a subset of cancers. Despite the general conservation of genetic structure amongst all HPV types, infection by the low‐risk types, whether in genital or head and neck sites, carries a negligible risk of malignant progression, and infections have a markedly different pathology. In this review, we will examine and discuss the interactions that the principal viral oncoproteins of the high‐risk mucosotrophic HPVs and their counterparts from the low‐risk group make with cellular target proteins, with a view to explaining the differences in their respective pathology.