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Solitary fibrous tumour of the kidney with sarcomatous overgrowth . Case report and review of the literature
Author(s) -
MAGRO GAETANO,
EMMANUELE CARMELA,
LOPES MARIA,
VALLONE GIUSEPPE,
GRECO PAOLO
Publication year - 2008
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2008.01012.x
Subject(s) - pathology , confusion , immunohistochemistry , cd34 , giant cell , context (archaeology) , multinucleate , kidney , sarcoma , s100 protein , biology , medicine , stem cell , microbiology and biotechnology , psychology , paleontology , psychoanalysis
Solitary fibrous tumour (SFT) rarely occurs in the kidney, with only one case exhibiting malignant behaviour. We report the case of a typical SFT of the kidney with sarcomatous overgrowth in a 34‐year‐old woman. This malignant component, grossly apparent as a nodular area arising in the context of the main tumour mass, consisted of CD34 + mitotically active atypical plump spindle‐ to epithelioid‐shaped cells, including pleomorphic multinucleated giant cells. A novel immunohistochemical finding was diffuse and strong S‐100 protein expression by sarcomatous cells. This should be kept in mind by pathologists to avoid confusion with other S‐100 protein‐positive malignant neoplasms.