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If it's not CK5/6 positive, TTF‐1 negative it's not a squamous cell carcinoma of lung
Author(s) -
DOWNEY PAUL,
CUMMINS ROBERT,
MORAN MARGARET,
GULMANN CHRISTIAN
Publication year - 2008
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2008.00932.x
Subject(s) - adenocarcinoma , tissue microarray , histopathology , pathology , lung cancer , medicine , basal cell , lung , carcinoma , cell , cancer , immunohistochemistry , cancer research , biology , genetics
Novel targeted treatment of non‐small cell lung cancer (NSCLC) requires accurate classification of NSCLC as squamous cell carcinoma (SCC) and adenocarcinoma (AC). This study details the CK5/6 and TTF‐1 immunoprofile of surgical resections of 45 NSCLCs (24 ACs and 21 SCCs) in tissue microarrays. All SCCs were CK5/6 positive, TTF‐1 negative. 20 of 24 adenocarcinomas had the reverse pattern. In conclusion, all SCCs in this study were CK5/6 positive and TTF‐1 negative, and therefore tumours that do not display this phenotype are unlikely to be SCCs. CK5/6 and TTF‐1 is therefore a practical panel for the distinction between pulmonary SCC from AC in routine histopathology practice.