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In vivo prion protein intestinal uptake in fish
Author(s) -
DALLA VALLE ANDREA ZE,
IRITI MARCELLO,
FAORO FRANCO,
BERTI CRISTIANA,
CIAPPELLANO SALVATORE
Publication year - 2008
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2008.00863.x
Subject(s) - rainbow trout , gastrointestinal tract , in vivo , biology , intestinal mucosa , trout , fish <actinopterygii> , small intestine , pathology , medicine , endocrinology , biochemistry , fishery , microbiology and biotechnology
Intestinal uptake of abnormal prion protein (PrP Sc ), the pathologicalagent involved in transmissible spongiform encephalopathies (TSEs), has beeninvestigated in rainbow trout ( Oncorhynchus mykiss ). Experimentalprocedures were conducted in vivo by immunohistological PrP Sc localization in intestine and pyloric caeca after forced feeding ofinfected material. Results indicate that PrP Sc was absorbed by theintestinal mucosa and that it persisted in the fish gastrointestinal tract forup to 3 days in pyloric caeca and for up to 7 days in the distal intestine. It did not remain longer than 15 days in the fish intestine; furthermore, it did not cross the intestinal barrier.