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Aberrant methylation in promoter regions of cyclin‐dependent kinase inhibitor genes in adenoid cystic carcinoma of the salivary gland
Author(s) -
DAA TSUTOMU,
KASHIMA KENJI,
KONDO YOSHIYUKI,
YADA NAOMI,
SUZUKI MASASHI,
YOKOYAMA SHIGEO
Publication year - 2008
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2008.00773.x
Subject(s) - adenoid cystic carcinoma , carcinogenesis , cancer research , biology , dna methylation , methylation , epigenetics , salivary gland , gene silencing , gene , tumor suppressor gene , cyclin dependent kinase , cell cycle , microbiology and biotechnology , carcinoma , genetics , gene expression , biochemistry
Adenoid cystic carcinoma (ACC) is a common malignant neoplasm of the salivary gland. The mechanism underlying ACC carcinogenesis is not fully elucidated, although data on associated genetic alterations are accumulating. Cyclin‐dependent kinase inhibitors (CKIs) act as tumor suppressors in various cancers, and aberrant methylation in the CKI gene promoter region has been linked to gene silencing and downregulation of expression. The present study investigated methylation of CKI genes, p15, p18, p19, p21 , and p27 , in 34 cases of ACC. We found frequent and plural methylations of these genes in most cases (68.8% in p15 , 90.3% in p18 , 78.8% in p19 , 92.3% in p21 , and 26.5% in p27 ). Cell cycle disruption induced by these epigenetic aberrations might be important in the tumorigenesis of ACC.