Premium
An Asian variant of intravascular lymphoma: unique clinical and pathological manifestation in the gallbladder
Author(s) -
KURODA N.,
MIZOBUCHI M.,
SHIMAMURA Y.,
TANIGUCHI Y.,
DAIBATA M.,
MIYOSHI I.,
ICHIMURA T.,
BEPPU H.,
OHARA M.,
HIROUCHI T.,
MIZUNO K.,
LEE G. H.
Publication year - 2007
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2007.apm_578.x
Subject(s) - medicine , pathology , gallbladder , lymphoma , autopsy , parenchyma , cholecystitis , pathological , bone marrow , intravascular large b cell lymphoma , edema , connective tissue , cholecystectomy
We here present a rare case of intravascular lymphoma (IVL) in a Japanese man. 4 months after cholecystectomy due to cholecystitis, a diagnosis of intravascular lymphoma (IVL) was strongly suspected. Lymphoma cells were diffusely observed in the bone marrow parenchyma, but were absent in the vascular spaces. The patient died of respiratory failure and at autopsy a small number of lymphoma cells in the extravascular parenchyma of the adrenal gland and bone marrow were seen. Serial sections of the surgically resected gallbladder retrospectively confirmed the diagnosis of IVL. In addition, congestion and edema were observed in the connective tissue layer. It is possible that edema or ischemia in the gallbladder wall or at other anatomic sites due to the circulation disturbance induced by the intravascular obstruction of lymphoma cells may have caused the initial symptoms. In conclusion, clinicians and pathologists should keep in mind that the gallbladder may be initially involved in IVL.