Premium
E‐cadherin, β‐catenin, invasion and lymph node metastases in canine malignant mammary tumours
Author(s) -
DE MATOS AUGUSTO JOSÉ FERREIRA,
LOPES CÉLIA CRISTINA CARREIRAS,
FAUSTINO AUGUSTO MANUEL RODRIGUES,
CARVALHEIRA JÚLIO GIL VALE,
RUTTEMAN GERARD ROEL,
GÄRTNER MARIA DE FÁTIMA RODRIGUES MOUTINHO
Publication year - 2007
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2007.apm_544.x
Subject(s) - pathology , cadherin , catenin , lymph node , mammary carcinoma , mammary gland , medicine , lymph , biology , carcinoma , cancer research , cancer , breast cancer , microbiology and biotechnology , wnt signaling pathway , signal transduction , genetics , cell
Recent studies of canine malignant mammary tumours suggest that reduction of E‐cadherin and/or β‐catenin correlates with invasive behaviour and lymph node metastasis. The aims of this study were to examine the interrelationships between the expression of E‐cadherin and β‐catenin, and the relationship between the expression of E‐cadherin and/or β‐catenin and the mode of growth and metastatic capacity of canine malignant mammary tumours. 90 spontaneous malignant tumours and local and regional lymph nodes were studied. A significant relationship was evidenced between membranous expression of E‐cadherin and β‐catenin (p=0.0027), but not between E‐cadherin and cytoplasmic β‐catenin. Only E‐cadherin as a separate factor was significantly related to tumour invasion (p=0.0072) and lymph node metastasis (p=0.0001). Neither membranous nor cytoplasmic β‐catenin expression was significantly related to either of these phenomena.