Premium
Primary hepatic clear cell myomelanocytic tumor
Author(s) -
LARBCHAROENSUB NOPPADOL,
KARNSOMBUT PATCHAREE,
JATCHAVALA JANJIRA,
WASUTIT YODYING,
NITIYANANT PRAWAT
Publication year - 2007
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2007.00733.x
Subject(s) - desmin , perivascular epithelioid cell , pathology , epithelioid cell , eosinophilic , endoplasmic reticulum , biology , population , cytoplasm , hmb 45 , intermediate filament , cell , vimentin , medicine , immunohistochemistry , microbiology and biotechnology , cytoskeleton , genetics , environmental health
A case of hepatic clear cell myomelanocytic tumor in a 31‐year‐old woman presenting clinically with abdominal pain is reported. Histopathologic examination showed a lesion characterized by a population of large epithelioid cells with clear or eosinophilic granular cytoplasm, rich in glycogen. Immunohistochemically, the tumor cells were positive for HMB‐45, Melan‐A and muscle‐specific actin, but negative for epithelial markers, desmin, S‐100 protein, and neuroendocrine markers. Ultrastructurally, the tumor cells had abundant glycogen, well‐developed rough endoplasmic reticulum, microtubules and aberrant melanosomes. Clinical and pathologic features with a brief review of the relevant literature for hepatic CCMMT as a variant of perivascular epithelioid cell tumor (PEComa) are discussed.