Premium
How to outwit the enemy: dendritic cells face Salmonella
Author(s) -
BIEDZKASAREK MARTA,
EL SKURNIK MIKA
Publication year - 2006
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2006.apm_465.x
Subject(s) - typhoid fever , salmonella , serotype , salmonella enterica , microbiology and biotechnology , immune system , biology , context (archaeology) , antigen , immunology , bacteria , salmonella typhi , virology , escherichia coli , gene , genetics , paleontology
Salmonella enterica serovar Typhi causes typhoid fever, a serious life‐threatening systemic infection. In mice, a similar disease is caused by Salmonella enterica serovar Typhimurium. During typhoid fever, soon after attachment to the mucosal surface of the gut, bacteria come into contact with the dendritic cells (DCs). The ability to sample antigens, process and present them to naıÐve and mature T cells, in the context of major histocompatibility complex molecules, makes DCs indispensable for mounting a specific and efficient immune response to invading pathogens. These bacteria, however, have evolved a number of mechanisms to interfere with or subvert DC functions. This review aims to describe how Salmonella clashes with dendritic cells at different stages of infection as well as the war strategies of these two opposing sides.