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T‐cell/histiocyte‐rich large B‐cell lymphoma associated with a near‐tetraploid karyotype and complex genetic abnormalities
Author(s) -
DE LEVAL LAURENCE,
HARRIS NANCY LEE,
LAMPERTZ SERGE,
HERENS CHRISTIAN
Publication year - 2006
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2006.apm_458.x
Subject(s) - bcl6 , karyotype , histiocyte , lymphoma , biology , pathology , cytogenetics , chromosome , b cell , genetics , medicine , immunology , gene , germinal center , antibody
Cytogenetic data for T‐cell/histiocyte‐rich large B‐cell lymphoma (THRLBCL) are scarcely available. We report here a case of THRLBCL with a near‐tetraploid karyotype and complex chromosomal aberrations, without rearrangement of BCL2 or BCL6, and characterized pathologically by a variegated morphologic appearance with areas resembling nodular lymphocyte‐predominant Hodgkin's lymphoma (NLPHL).