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Preoperative CA125 as a prognostic factor in stage I epithelial ovarian cancer
Author(s) -
PETRI ANETTE LYKKE,
HØGDALL ESTRID,
CHRISTENSEN IB JARLE,
KJAER SUSANNE KRÜGER,
BLAAKÆR JAN,
HØGDALL CLAUS KIM
Publication year - 2006
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2006.apm_397.x
Subject(s) - medicine , stage (stratigraphy) , epithelial ovarian cancer , ovarian cancer , oncology , gynecology , cancer , gastroenterology , paleontology , biology
The purpose of the present study was to evaluate preoperative CA125 as a prognostic factor in stage I epithelial ovarian cancer (EOC). Preoperative serum CA125 levels from 118 women with FIGO (International Federation of Gynaecology and Obstetrics) stage I EOC were analysed and the prognostic value was evaluated and compared with other prognostic factors (age, grade, substages, histologic type). By the Kaplan‐Meier estimate we demonstrated that patients with stage I EOC and preoperative serum CA125 levels <65 U/mL had a significantly longer survival compared to stage I EOC patients with preoperative serum CA125≥65 U/mL (p=0.01). The results from the present study may be useful for decision making respecting postoperative chemotherapy in stage I EOC patients. Serum CA125 levels might therefore be included as a prognostic factor in future clinical trials of stage I EOC.