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Mutational analysis of MYC in common epithelial cancers and acute leukemias
Author(s) -
LEE JONG WOO,
SOUNG YOUNG HWA,
KIM SU YOUNG,
NAM SUK WOO,
PARK WON SANG,
LEE JUNG YOUNG,
YOO NAM JIN,
LEE SUG HYUNG
Publication year - 2006
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2006.apm_383.x
Subject(s) - cancer research , leukemia , medicine , biology , computational biology , genetics
In addition to chromosomal translocation, the MYC gene in the N‐terminal coding region showed clustered point mutations in Burkitt's lymphomas. A recent study showed that these point mutations inactivated the apoptosis activity of MYC and contributed to the tumor transformation. To see whether the point mutations of MYC are involved in tumors besides Burkitt's lymphomas, we analyzed the N‐terminal cluster region of the mutations in 507 cancers from gastric, colorectal, breast and lung carcinomas, and acute leukemias, by polymerase chain reaction‐based single‐strand conformation polymorphism assay. However, there was no somatic mutation of the MYC gene in the cancers. The data suggest that the point mutation of the MYC gene in the N‐terminal domain may be very rare and may not contribute to the development of common human cancers besides Burkitt's lymphomas.