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Female urethral adenocarcinoma with a heterogeneous phenotype
Author(s) -
KURODA N.,
SHIOTSU T.,
OHARA M.,
HIROUCHI T.,
MIZUNO K.,
MIYAZAKI E.
Publication year - 2006
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2006.apm_345.x
Subject(s) - adenocarcinoma , clear cell adenocarcinoma , pathology , cribriform , columnar cell , biopsy , medicine , cystoscopy , urethra , papillary adenocarcinoma , urinary bladder , immunohistochemistry , epithelium , urology , cancer , clear cell , alternative medicine
We here report a very rare case of female urethral adenocarcinoma. A 77‐year‐old woman presented with urinary retention. Cystoscopy showed a urethral tumor and the biopsy material showed adenocarcinoma. Macroscopically, the tumor measuring 3.0×3.0×2.4 cm was predominantly observed around the periurethral area on the proximal side. Histologically, patterns of columnar/mucinous adenocarcinoma, clear cell adenocarcinoma and papillary/micropapillary carcinoma were observed, but there was no evidence of a cribriform pattern. Immunohistochemically, neoplastic cells of at least one of three components were positive for CK7 and CK20 or CA125. We suggest that female urethral adenocarcinoma with a histologically and immunohistochemically heterogeneous phenotype may originate from cells within urethral or paraurethral tissue, such as urethritis glandularis or intestinal metaplastic epithelium and Mullerian tissue.