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Inhibition of T‐cell responses by CD4 on an antigen‐presenting cell
Author(s) -
HANSEN TORBJØRN
Publication year - 2006
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2006.apm_339.x
Subject(s) - raji cell , peripheral blood mononuclear cell , antigen presenting cell , antigen , chemistry , immunology , t cell , t lymphocyte , microbiology and biotechnology , immune system , cytotoxic t cell , cell , biology , in vitro , biochemistry
In addition to T‐helper cells, CD4 is expressed on monocytes, macrophages and dendritic cells. To see whether CD4 molecules on antigen‐presenting cells affect T‐cell responses, we expressed CD4 on Raji cells, and compared positive and negative cells as stimulator cells for peripheral blood mononuclear cells in mixed lymphocyte reactions. We found that expression of CD4 on Raji had an inhibitory effect on production of IFN‐γ and other cytokines.