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Primary peritoneal carcinoma: a rare neoplasm with pleomorphic trophoblastic morphology
Author(s) -
MADSEN CHARLOTTE WINTHER,
HASSELBY JANE PREUSS,
LARSEN LISE GRUPE
Publication year - 2006
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2006.apm_293.x
Subject(s) - pathology , immunohistochemistry , carcinoma , neoplasm , infiltration (hvac) , peritoneum , staining , medicine , physics , thermodynamics
We report a case of primary peritoneal carcinoma with trophoblastic morphology in a 78‐year‐old woman, diagnosed by histological and immunohistochemical analysis of surgically resected specimens, including the omentum and part of the small bowel. Microscopically, the resected specimens showed diffuse infiltration of a poorly differentiated tumor. Numerous large, often multinucleated cells were seen, and mitotic figures were frequent. Immunohistochemical staining showed a positive reaction for most cytokeratins, EP4, EMA, CA‐125, Glut1, WT1, β‐hCG and PLAP. We reached a diagnosis of primary peritoneal carcinoma with trophoblastic morphology. To our knowledge this morphology of a primary peritoneal carcinoma has not been described previously.