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Ovarian ependymoma
Author(s) -
ERDOǦAN GÜLGÜN,
ÖZEL ESIN,
PEŞTERELI HADICE ELIF,
SALAR ZEKI,
TIRAK BILAL,
KARAVELI ŞEYDA
Publication year - 2005
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2005.apm_10.x
Subject(s) - ependymoma , pathology , glial fibrillary acidic protein , nucleolus , biology , immunohistochemistry , ependymal cell , gfap stain , anatomy , anaplasia , cytoplasm , medicine , microbiology and biotechnology
A 76‐year‐old woman presented with a large calcifying mass behind the bladder. The tumor contained solid areas of a yellowish white color. Microscopic examination revealed highly cellular solid areas with many typical ependymal perivascular pseudorosettes. The cells contained uniform round‐to‐oval nuclei, some of which had irregular contours, clumped chromatin and occasional prominent nucleoli. There was widespread geographic necrosis and there were 5 atypical mitotic figures per 10 high power fields. Glial fibrillary acidic protein (GFAP) immunopositivity was observed in the cytoplasm of the tumor cells. Based on the histopathologic and immunohistochemical features, the tumor was diagnosed as an anaplastic ependymoma. This is to the best of our knowledge only the second case of anaplastic ependymoma in the medical literature.