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Follicular lymphoid hyperplasia of the oral cavity representing progressive transformation of germinal center
Author(s) -
KOJIMA MASARU,
NAKAMURA SHIGEO,
IIJIMA MISA,
YOSHIZUMI TAKASHI,
SAKATA NORIYUKI,
MASAWA NOBUHIDE
Publication year - 2005
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2005.apm1130311.x
Subject(s) - germinal center , follicular phase , lymphoid hyperplasia , transformation (genetics) , lymphatic system , pathology , center (category theory) , medicine , biology , immunology , genetics , chemistry , lymphoma , b cell , antibody , gene , crystallography
Follicular lymphoid hyperplasia (FLH) of the oral cavity is a rare and poorly understood lymphoproliferative disorder. We present a case of FLH of the oral cavity presenting with progressive transformation of germinal center (PTGC). The patient was a 49‐year‐old Japanese woman presenting with a hard mass in the right cheek. The resected specimen contained numerous lymphoid follicles with active germinal centers and a portion of the lymphoid follicles exhibited PTGC. The PTGCs contained a few large lymphoid cells resembling lymphocytic and histiocytic Reed‐Sternberg cells of nodular lymphocyte‐predominant Hodgkin lymphoma. The PTGC was surrounded by groups of epithelioid cells. In situ hybridization studies demonstrated strong expression of Epstein‐Barr virus (EBV)‐encoded small RNA in scattered large lymphoid cells in the PTGC. Although the etiology of FLH of the oral cavity remains unclear, the present case suggests that a subset of FLH of the oral cavity appears to be an EBV‐associated lymphoproliferative disorder.