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The value of tartrate resistant acid phosphatase (TRAP) immunoreactivity in diagnosis of hairy cell leukemia
Author(s) -
AKKAYA HAMPAR,
DOGAN ONER,
AGAN MEHMET,
DINCOL GUNCAG
Publication year - 2005
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2005.apm1130302.x
Subject(s) - hairy cell leukemia , pancytopenia , hairy cell , bone marrow , pathology , microbiology and biotechnology , medicine , leukemia , tartrate resistant acid phosphatase , cytoplasm , biopsy , antibody , chemistry , cell , acid phosphatase , gastroenterology , immunology , biology , biochemistry , enzyme
Hairy cell leukemia (HCL) is a rare chronic B‐cell lymphoproliferative disorder characterized by splenomegaly, pancytopenia, and circulating atypical lymphocytes with circumferential cytoplasmic projections. We investigated the specificity and the sensitivity of anti‐TRAP antibody immunoreactivity in 57 cases of HCL. We found that there is a statistically highly significant difference between TRAP immunoreactivities of the study and the control groups, and HCL can be diagnosed by TRAP immunoreactivity in bone marrow trephine biopsy materials with a specificity of 98.27 % and a sensitivity of 100%.