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Endometrial adenosquamous carcinoma with osteoclast‐like giant cells: immunohistochemistry and histogenesis
Author(s) -
IMURA JOHJI,
TOMITA SHIGEKI,
ONO YUKO,
INABA FUJIYUKI,
YAMAZAKI TATSUO,
FUKASAWA ICHIO,
INABA NORIYUKI,
FUJIMORI TAKAHIRO
Publication year - 2005
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2005.apm1130208.x
Subject(s) - pathology , histogenesis , adenosquamous carcinoma , giant cell , carcinoma , cd68 , lymph node , histiocyte , stromal cell , stroma , immunohistochemistry , medicine , adenocarcinoma , cancer
Primary extraskeletal epithelial neoplasms containing osteoclast‐like giant cells (OGCs) are rare. We herein describe a case of adenosquamous carcinoma that developed in the endometrium together with non‐neoplastic OGCs. The patient was a 72‐year‐old woman who underwent radical hysterectomy with salpingo‐oophorectomy and lymph node dissection after being diagnosed with uterine cancer. Histologically, the tumor was found to be an adenosquamous carcinoma containing a large number of OGCs and mononuclear cells (MNCs) that had infiltrated into the stroma. Immunohistochemically, the OGCs and MNCs stained strongly positive for KP‐1 and alpha‐1‐antichymotrypsin, and negative for the epithelial markers epithelial membrane antigen (EMA) and cytokeratins. These findings suggest that the OGCs and MNCs in this patient's tumor originated from monocytes/histiocytes, and most likely developed as part of the stromal reaction to the neoplasm.