Premium
Loss of caspase‐2, ‐6 and ‐7 expression in gastric cancers
Author(s) -
YOO NAM JIN,
LEE JONG WOO,
KIM YUN JU,
SOUNG YOUNG HWA,
KIM SU YOUNG,
NAM SUK WOO,
PARK WON SANG,
LEE JUNG YOUNG,
LEE SUG HYUNG
Publication year - 2004
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2004.t01-1-apm1120602.x
Subject(s) - caspase , immunohistochemistry , apoptosis , cancer , caspase 3 , gastric mucosa , pathology , cancer cell , tissue microarray , biology , caspase 9 , cancer research , programmed cell death , medicine , stomach , biochemistry
Caspases play an essential role during apoptotic cell death, and alterations of caspases are known to contribute to human cancer development. In the current study, we analyzed the expression of caspase‐2, ‐6 and ‐7 in 120 gastric carcinomas by immunohistochemistry using a tissue microarray approach. Caspase‐2, ‐6 and ‐7 were expressed in 42 (35%), 63 (53%) and 39 (33%) of the gastric cancers, respectively. By contrast, the surface mucous cells and mucosal glandular cells in the normal gastric mucosa showed strong immunoreactivity for caspase‐2, ‐6 and ‐7. Taken together, these results indicate that caspase‐2, ‐6 and ‐7 expression in gastric cancer cells is decreased compared to in normal gastric mucosal cells, and suggest that loss of caspase‐2, ‐6 and ‐7 expression might be involved in the mechanisms of gastric cancer development.