Premium
Mutation of FADD gene is rare in human colon and stomach cancers
Author(s) -
SOUNG YOUNG HWA,
LEE JONG WOO,
KIM SU YOUNG,
NAM SUK WOO,
PARK WON SANG,
KIM SANG HO,
LEE JUNG YOUNG,
YOO NAM JIN,
LEE SUG HYUNG
Publication year - 2004
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2004.apm1120906.x
Subject(s) - fadd , cancer research , missense mutation , biology , mutation , germline mutation , gene , death domain , gene mutation , genetics , apoptosis , programmed cell death , caspase
Failure of apoptosis is one of the hallmarks of cancer. As an adaptor, FADD plays a crucial role during death receptor‐mediated apoptosis. We previously reported that the FADD gene is somatically mutated in non‐small cell lung cancers. To explore the possibility that the genetic alterations of the FADD gene might be involved in the development of other human cancers, we analyzed the entire coding region and all splice sites of the human FADD gene to detect somatic mutations in 116 stomach cancers and 98 colon cancers. Overall, we detected a somatic missense mutation of the FADD gene in a colon carcinoma, which was predicted to change an amino acid (R140H) in the death domain (DD) of the FADD protein. This is the first report of FADD gene mutation in gastrointestinal cancers, and our data suggest that the FADD gene is rarely mutated in human colon and stomach cancers.