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Expression of non‐membranous β‐catenin and γ‐catenin, c‐Myc and cyclin D1 in relation to patient outcome in human colon adenocarcinomas
Author(s) -
BONDI JOHAN,
BUKHOLM GEIR,
NESLAND JAHN M.,
BUKHOLM IDA R. K.
Publication year - 2004
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2004.apm1120109.x
Subject(s) - cyclin d1 , immunohistochemistry , catenin , wnt signaling pathway , proportional hazards model , medicine , beta catenin , cancer research , logistic regression , stage (stratigraphy) , oncology , pathology , cyclin , cell cycle , biology , cancer , signal transduction , paleontology , biochemistry
Non‐membranous β‐catenin and γ‐catenin, c‐Myc and cyclin D1 are key participants in the Wnt cell signalling pathway, in which aberrancies have been associated with malignant cell transformation. We assessed the independent prognostic value of these proteins in a clinical material. Tumours from a series of 162 patients operated on for Dukes' stage A, B and C colonic adenocarcinomas were analysed using semiquantitative immunohistochemistry and the results were related to patient outcome. Patients expressing nuclear β‐catenin in the primary tumour showed reduced survival compared to other patients (log rank p=0.028) and there was also an association with development of metastases follow‐up (logistic regression p=0.024). Using multivariate analysis (Cox regression) co‐expression of nuclear β‐catenin and c‐Myc turned out to be the strongest marker of impaired prognosis (p=0.001, HR 5.26, 95% CI 1.93–14.36). Expression of non‐membranous γ‐catenin, cyclin D1 and c‐Myc alone failed to have independent prognostic significance in our study.