Premium
Elevated number of cells secreting transforming growth factor β in Guillain‐Barré syndrome
Author(s) -
DAHLE C.,
KVARNSTRÖM M.,
EKERFELT C.,
SAMUELSSON M.,
ERNERUDH J.
Publication year - 2003
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2003.apm1111204.x
Subject(s) - elispot , guillain barre syndrome , secretion , immunology , transforming growth factor beta , peripheral blood mononuclear cell , transforming growth factor , tumor necrosis factor alpha , medicine , interleukin , cytokine , biology , t cell , immune system , in vitro , biochemistry
We used ELISPOT and cell ELISA to study secretion of IL‐4, IFN‐γ, TGF‐β, IL‐6, and TNF‐α by circulating mononuclear cells during the course of Guillain‐Barré syndrome (GBS). Compared to healthy controls, patients with GBS had higher numbers of TGF‐β‐secreting cells and the number of individuals with myelin‐peptide‐induced IL‐4 and TGF‐β secretion was higher in the GBS group. No significant differences were seen concerning the predominantly pro‐inflammatory cytokines IFN‐γ, IL‐6 or TNF‐α. Our findings indicate a down‐regulatory role for TGF‐β and IL‐4 in GBS.