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Long‐wave UVA offers partial protection against UVB‐induced immune suppression in human skin
Author(s) -
SKOV LONE,
VILLADSEN LOUISE,
ERSBØLL BJARNE K.,
SIMON JAN C.,
BARKER JONATHAN N. W. N.,
BAADSGAARD OLE
Publication year - 2000
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1600-0463.2000.tb00005.x
Subject(s) - sensitization , human skin , immune system , immunization , medicine , dermatology , irradiation , immunology , chemistry , biology , genetics , physics , nuclear physics
Ultraviolet‐B (UVB, 280–320 nm) interferes with the generation of cell‐mediated immunity to contact allergens applied epicutaneously on the irradiated site. To investigate whether pretreatment with UVA‐1 (340–400 nm) protects against the UVB‐induced immune suppression we sensitized human volunteers with diphenylcyclopropenone (DPCP) on normal buttock skin (n=12), on UVB‐irradiated buttock skin (n = 21), on buttock skin pretreated with UVA‐1 (n= 12), and on buttock skin pretreated with UVA‐1 and thereafter irradiated with UVB (n=22). Sensitization on UVB‐irradiated skin reduced the immunization rate to DPCP compared with sensitization on non‐irradiated skin (p<0.01) and skin pretreated with UVA‐1 (p<0.01). In contrast, the immunization rate in the group of volunteers sensitized on skin pretreated with UVA‐1 before UVB irradiation was significantly higher than the immunization rate in the group of volunteers sensitized on UVB‐irradiated skin alone (p<0.05). These results indicate that pretreatment with UVA‐1 under certain conditions offers partial protection against the UVB‐induced reduction in the immunization rates to epicutaneous allergens.