Premium
Menstrual exacerbation of schizophrenia symptoms
Author(s) -
Seeman M. V.
Publication year - 2012
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2011.01822.x
Subject(s) - exacerbation , premenstrual dysphoric disorder , schizophrenia (object oriented programming) , psychosis , estrogen , psychiatry , antipsychotic , menstrual cycle , psychology , medicine , psychological intervention , clinical psychology , hormone
Seeman MV. Menstrual exacerbation of schizophrenia symptoms. Objective: To better understand premenstrual exacerbations of schizophrenia in women and weigh treatment options. Method: A PubMed literature search was conducted, using the search terms ‘schizophrenia’, ‘psychosis’, ‘menstrual exacerbation’, ‘hormones’ and assessing relevance to premenstrual exacerbation of schizophrenia symptoms. Results: Exacerbations are usually distinguishable from periodic or menstrual psychosis, a relatively rare condition. Controversy continues about whether low estrogen periods of the month lead to an increase in schizophrenia symptoms among women of reproductive age or whether some women suffer from both schizophrenia and premenstrual dysphoric disorder (PMDD). No treatment trials of specific interventions have been conducted so that physicians must decide on a case‐by‐case basis whether to raise antipsychotic doses premenstrually, try estrogens or estrogen/progesterone combinations or selective estrogen receptor modulators, or target PMDD symptoms. Conclusion: Clinicians need to be aware of premenstrual symptom aggravation in a large minority of women with schizophrenia. Treatment strategies will depend on the nature of the symptoms that are exacerbated. Optimal treatment needs to be adjusted to the individual woman.