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Deep brain stimulation in the treatment of depression
Author(s) -
Blomstedt P.,
Sjöberg R. L.,
Hansson M.,
Bodlund O.,
Hariz M. I.
Publication year - 2011
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2010.01625.x
Subject(s) - deep brain stimulation , major depressive disorder , depression (economics) , rating scale , ventral striatum , refractory (planetary science) , internal capsule , psychology , gyrus , hamilton rating scale for depression , medicine , psychiatry , striatum , parkinson's disease , neuroscience , magnetic resonance imaging , radiology , disease , astrobiology , economics , macroeconomics , dopamine , developmental psychology , cognition , white matter , physics
Blomstedt P, Sjöberg RL, Hansson M, Bodlund O, Hariz MI. Deep brain stimulation in the treatment of depression. Objective: To present the technique of deep brain stimulation (DBS) and to evaluate the studies conducted on DBS in the treatment of therapy‐refractory major depressive disorder (MDD). Method: A review of the literature on DBS in the treatment of MDD was conducted. Results: The results of DBS in MDD have been presented in 2 case reports and 3 studies of 47 patients operated upon in 5 different target areas. Positive effects have been presented in all studies and side effects have been minor. DBS in the nucleus accumbens resulted in a mean reduction of Hamilton depression rating scale (HDRS) of 36% after 1 year and 30% of the 10 patients achieved remission. DBS in the internal capsule/ventral striatum resulted in a reduction of 44% after 1 year, and at the last evaluation after in mean 2 years, 40% of the 15 patients were in remission. The 20 patients with subcallosal cingulated gyrus DBS had a reduction of HDRS of 52% after 1 year, and 35% were within 1 point from remission or in remission. Conclusion: DBS is a promising treatment for therapy‐refractory MDD. The published experience is, however, limited, and the method is at present an experimental therapy.