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Early identification of non‐remission in first‐episode psychosis in a two‐year outcome study
Author(s) -
Simonsen E.,
Friis S.,
Opjordsmoen S.,
Mortensen E. L.,
Haahr U.,
Melle I.,
Joa I.,
Johannessen J. O.,
Larsen T. K.,
Røssberg J. I.,
Rund B. R.,
Vaglum P.,
McGlashan T. H.
Publication year - 2010
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2010.01598.x
Subject(s) - dup , psychosis , schizophrenia (object oriented programming) , psychology , psychiatry , univariate analysis , medicine , multivariate analysis , pediatrics , biochemistry , chemistry , gene duplication , gene
Simonsen E, Friis S, Opjordsmoen S, Mortensen EL, Haahr U, Melle I, Joa I, Johannessen JO, Larsen TK, Røssberg JI, Rund BR, Vaglum P, McGlashan TH. Early identification of non‐remission in first‐episode psychosis in a two‐year outcome study. Objective: To identify predictors of non‐remission in first‐episode, non‐affective psychosis. Method: During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years. Results: One hundred and twenty‐nine patients (43%) remained psychotic at 3 months and 48 patients (16.4%) remained psychotic over 2 years. When we compared premorbid and baseline data for the three groups, the non‐remitted ( n = 48), remitted for <6 months ( n = 38) and for more than 6 months ( n = 207), duration of untreated psychosis (DUP) was the only variable that significantly differentiated the groups (median DUP: 25.5, 14.4 and 6.0 weeks, respectively). Three months univariate predictors of non‐remission were being single, longer DUP, core schizophrenia, and less excitative and more negative symptoms at baseline. Two‐year predictors were younger age, being single and male, deteriorating premorbid social functioning, longer DUP and core schizophrenia. In multivariate analyses DUP, negative and excitative symptoms predicted non‐remission at 3 months, but only DUP predicted at 2 years. Conclusion: Long DUP predicted both 3 month and 2‐year non‐remission rates in first‐episode psychosis.