Premium
Default mode network connectivity as a predictor of post‐traumatic stress disorder symptom severity in acutely traumatized subjects
Author(s) -
Lanius R. A.,
Bluhm R. L.,
Coupland N. J.,
Hegadoren K. M.,
Rowe B.,
Théberge J.,
Neufeld R. W. J.,
Williamson P. C.,
Brimson M.
Publication year - 2010
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2009.01391.x
Subject(s) - default mode network , precuneus , amygdala , traumatic stress , psychology , functional magnetic resonance imaging , posterior cingulate , functional connectivity , magnetic resonance imaging , anterior cingulate cortex , correlation , clinical psychology , medicine , audiology , psychiatry , neuroscience , cognition , radiology , geometry , mathematics
Objective: The goal of this study was to investigate the relationship between default mode network connectivity and the severity of post‐traumatic stress disorder (PTSD) symptoms in a sample of eleven acutely traumatized subjects. Method: Participants underwent a 5.5 min resting functional magnetic resonance imaging scan. Brain areas whose activity positively correlated with that of the posterior cingulate/precuneus (PCC) were assessed. To assess the relationship between severity of PTSD symptoms and PCC connectivity, the contrast image representing areas positively correlated with the PCC was correlated with the subjects’ Clinician Administered PTSD Scale scores. Results: Results suggest that resting state connectivity of the PCC with the perigenual anterior cingulate and the right amygdala is associated with current PTSD symptoms and that correlation with the right amygdala predicts future PTSD symptoms. Conclusion: These results may contribute to the development of prognostic tools to distinguish between those who will and those who will not develop PTSD.