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Clinical and serotonergic predictors of non‐affective acute remitting psychosis in patients with a first‐episode psychosis
Author(s) -
Arranz B.,
San L.,
Ramírez N.,
Dueñas R. M.,
Perez V.,
Salavert J.,
Corripio I.,
Alvarez E.
Publication year - 2009
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2008.01253.x
Subject(s) - psychosis , serotonergic , schizophrenia (object oriented programming) , psychology , logistic regression , psychiatry , delusion , depressive symptoms , depression (economics) , paranoid schizophrenia , clinical psychology , medicine , serotonin , anxiety , receptor , economics , macroeconomics
Objective: The study aimed to establish clinical predictors of non‐affective acute remitting psychosis (NARP) and assess whether these patients showed a distinct serotonergic profile. Method: First‐episode never treated psychotic patients diagnosed of paranoid schizophrenia ( n = 35; 21 men and 14 women) or NARP ( n = 28; 15 men and 13 women) were included. Results: NARP patients showed significantly lower negative symptomatology, better premorbid adjustment, shorter duration of untreated psychosis, more depressive symptomatology and a lower number of 5‐HT2A receptors than the paranoid schizophrenia patients. In the logistic regression, the four variables associated with the presence of NARP were: low number of 5‐HT2A receptors; good premorbid adjustment; low score in the item ‘hallucinatory behaviour’ and reduced duration of untreated psychosis. Conclusion: Our findings support the view that NARP is a highly distinctive condition different from either affective psychosis or other non‐affective psychosis such as schizophrenia, and highlight the need for its validation.