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Anterior cingulate activation in antipsychotic‐naïve first‐episode schizophrenia
Author(s) -
Yücel M.,
Brewer W. J.,
Harrison B. J.,
Fornito A.,
O'Keefe G. J.,
Olver J.,
Scott A. M.,
Egan G. F.,
Velakoulis D.,
McGorry P. D.,
Pantelis C.
Publication year - 2007
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2006.00902.x
Subject(s) - anterior cingulate cortex , schizophrenia (object oriented programming) , antipsychotic , psychology , cingulate cortex , stroop effect , psychiatry , error related negativity , psychosis , medicine , neuroscience , cognition , central nervous system
Objective: Anterior cingulate (ACC) hypo ‐activity is commonly observed in chronically ill schizophrenia patients. However, it is unclear whether this is secondary to persistent illness and/or medication. Method: We examined eight antipsychotic‐naïve first‐episode patients and matched healthy controls undergoing PET scanning while performing the Stroop task. Results: Group‐averaged and single‐subject analyses showed ACC activation in both controls and patients, albeit in different sub‐regions (paracingulate and cingulate respectively). A direct comparison revealed relative under‐activity of the left paracingulate cortex in patients. Conclusion: These findings suggest that the more pervasive hypo ‐activation observed in chronic patients may be secondary to persistent illness and/or medication.
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