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C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients
Author(s) -
Hoenicka J.,
Aragüés M.,
RodríguezJiménez R.,
Ponce G.,
Martínez I.,
Rubio G.,
JiménezArriero M. A.,
Palomo T.
Publication year - 2006
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.2006.00874.x
Subject(s) - snp , genotype , single nucleotide polymorphism , allele , schizophrenia (object oriented programming) , polymorphism (computer science) , genetics , allele frequency , biology , medicine , gene , psychiatry
Objective: The objective was to confirm whether a homozygous genotype for the C957 allele of the C957T DRD2 gene single nucleotide polymorphism (SNP) is associated with schizophrenia in an independent study population. Method: We examined the genotypic distribution of this SNP in a set of clinically ascertained schizophrenic patients ( n = 131) and age‐matched control subjects ( n = 364). Individuals were genotyped using automated analysis of fluorescently labeled PCR products. Results: The distribution of grouped genotypes for the C957T DRD2 SNP (CC vs. CT, TT) showed that C homozygote genotype was over‐represented in our patient sample when compared with control subjects. This difference reaches the statistical significance ( χ 2 = 7.0; df = 1; P = 0.008; OR = 2.05; % CI 1.2–3.4). Conclusion: The findings of this study provide additional evidence that genetic variation at the DRD2 gene plays an important role in the vulnerability to schizophrenia.